Process development. Multiple step syntheses of active pharmaceutical ingredients.

• Project management skills. Led a team of Ph.D. chemists, analytical chemist and associate chemists. Developed a synthesis of a new ADHD drug. Scaled up to 750 gallon reactor size. Filed regulatory documents.
• Developed a new synthesis of a steroid drug. Cut the number of steps by 2/3. Improved the overall yield by 50%. Scaled up the process to 250 kilogram size
• Developed a new synthesis of two opiate drugs. Scaled up to 500 gallon reactor size. Eliminated an impurity to conform new FDA guidelines
• Optimized a 2000 gallon scale catalytic hydrogenation step of an existing plant process
• Developed a scaleable method for the separation of opium alkaloids

• Synthesized biologically active molecules for crop protection such as heterocycles, natural products, carbohydrates, glycosides, nucleosides, monofluoro sugars. Synthesized 20+ C-aryl sugar, C-aryl monofluorosugar analogs of a known natural insecticide
• Developed a multistep synthesis of an enantiomerically pure insecticide compound for field test
• Managed multiple research projects with external academic and industrial research groups. Created a network of international scientific research groups willing to carry out contract synthesis projects to promote business objectives. Generated 5 hit areas for further follow up work
• Follow up work on active compounds from High Throughput Screening. Worked on 7-11 hit areas annually. Synthesized 20-40 targeted analogs per hit areas. Good knowledge of Structure Activity Relationships
• Collected relevant scientific information using STN Express, SciFinder and Beilstein Crossfire
• Evaluated combinatorial libraries using Spotfire program. Optimized the diversity of the acquired libraries, eliminated redundant libraries from different vendors, achieving significant savings
• Prepared technical reports, manuscripts and presentations using Microsoft Office, ISIS Base, ISIS Draw, and ChemDraw
• Optimized synthetic targets by utilizing molecular modeling programs such as Cerius2
• Participated in the work of interdisciplinary groups with biologists and computational chemist to optimize synthetic targets
• Trained and supervised four research associates to independently carry out research programs

• Developed a method for the conversion of C-aryl glycosides into transition metal pentacarbonyl carbene complexes
• Synthesized analogues of a highly functionalized C-aryl glycoside natural product via Doetz-benzannulation reaction
• Mentored students, was involved in teaching activities

• Synthesized highly reactive transition metal fluorocarbene carbonyl complexes and investigated their synthetic potential in the formation of complex monofluoro ring systems, fluorinated beta lactams
• Established the proper structure of an unusually stable monofluoro amino carbene complex by X-ray analysis
• Participated in interdepartmental research projects. Synthesized a series of photochemical dies for an ongoing research project
• Safe handling of aggressive and air sensitive materials on a daily basis

• Developed novel synthetic routes for existing API-s. Kilo lab preparation of advanced intermediates
• Supervised the work of assistant chemists
• Participated in the work of interdisciplinary groups with pharmacologists to optimize synthetic targets