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1021 Trenton Place
Wilmington, DE 19801
Tel: (302) 426-1351
Cell: (302) 357-5428
E-mail: emkeskeny@yahoo.com
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A research scientist position in a pharmaceutical industry where outstanding expertise in synthetic organic chemistry and excellent problem solving and interpersonal skills will promote laboratory goals and advance company business objectives. |
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- Process Developement
- Heterocyclic
chemistry
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Asymmetric synthesis
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Optical resolution
- Catalytic
reactions
- Photochemistry
- Natural
products
- Carbohydrates
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- Glycosides
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Monofluoro sugars
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Parallel synthesis
- HTS
follow up
- On-line
searches
- Database
programs
- Molecular
modeling
- Technical
writing
- Language
skills
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DuPont Stine-Haskell Research Center
Senior Research Scientist 1996
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1994-2001 |
Participated
in the work of several research groups including
insecticide discovery, natural products discovery
and lead generation groups.
- Synthesized biologically active molecules for crop protection such as heterocycles, natural products, carbohydrates, glycosides, nucleosides, monofluoro sugars. Synthesized 20+ C-aryl sugar, C-aryl monofluorosugar analogs of a known natural insecticide
- Developed a multistep synthesis of an enantiomerically pure insecticide compound for field test
- Managed multiple research projects with external academic and industrial research groups. Created a network of international scientific research groups willing to carry out contract synthesis projects to promote business objectives. Generated 5 hit areas for further follow up work
- Follow up work on active compounds from High Throughput Screening. Worked on 7-11 hit areas annually. Synthesized 20-40 targeted analogs per hit areas. Good knowledge of Structure Activity Relationships
- Collected relevant scientific information using STN Express, SciFinder and Beilstein Crossfire
- Evaluated combinatorial libraries using Spotfire program. Optimized the diversity of the acquired libraries, eliminated redundant libraries from different vendors, achieving significant savings
- Prepared technical reports, manuscripts and presentations using Microsoft Office, ISIS Base, ISIS Draw, and ChemDraw
- Optimized synthetic targets by utilizing molecular modeling programs such as Cerius2
- Participated in the work of interdisciplinary groups with biologists and computational chemist to optimize synthetic targets
- Trained and supervised four research associates to independently carry out research programs
Selected
Research Projects
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Brown University, Department of Chemistry
Postdoctoral Fellowship
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1992-1994 |
- Developed a method for the conversion of C-aryl glycosides into transition metal pentacarbonyl carbene complexes
- Synthesized analogues of a highly functionalized C-aryl glycoside natural product via Doetz-benzannulation reaction
- Mentored
students, was involved in teaching activities
Research Overview
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University of New York at Albany, Department
of Chemistry
Postdoctoral Fellowship
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1990-1992 |
- Synthesized
highly reactive transition metal fluorocarbene
carbonyl complexes and investigated their synthetic
potential in the formation of complex monofluoro
ring systems, fluorinated beta lactams
- Established
the proper structure of an unusually stable
monofluoro amino carbene complex by X-ray analysis
- Participated
in interdepartmental research projects. Synthesized
a series of photochemical dies for an ongoing
research project
- Safe
handling of aggressive and air sensitive materials
on a daily basis
Research
Overview
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Richter Gedeon Pharmaceutical Works
Research Scientist
Senior Research Scientist 1988
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1985-1990 |
Lead
development and optimization. Multistep syntheses
for pharmacologically active molecules such
as antidepressants, sedatives and antihistamine
compounds
- Developed novel synthetic routes for existing API-s. Kilo lab preparation of advanced intermediates
- Supervised
the work of assistant chemists
- Participated
in the work of interdisciplinary groups with
pharmacologists to optimize synthetic targets
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M.Sc. Organic Chemistry
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Technical University of Budapest |

1985 |
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B.Sc. Organic Chemistry
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Technical University of Budapest |

1983 |
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