1021 Trenton Place Wilmington, DE 19801 Tel: (302) 426-1351 E-mail: erno@keskeny.com   OBJECTIVE   A research scientist position in a pharmaceutical industry where outstanding expertise in synthetic organic chemistry and excellent problem solving and interpersonal skills will promote laboratory goals and advance company business objectives.   BACKGROUND SUMMARY   Heterocyclic chemistry Asymmetric synthesis Optical resolution Catalytic reactions Photochemistry Biologically active molecules Natural products ß-Lactams Carbohydrates Glycosides Monofluoro sugars Parallel synthesis HTS follow up On-line searches Database programs Molecular modeling Technical writing Language skills   PROFESSIONAL EXPERIENCE AND SELECTED ACCOMPLISHMENTS   Johnson Matthey Pharmaceutical Materials Division Senior Research Scientist 2001-present Process development. Multiple step syntheses of highly active controlled substances. Generic drug research. DuPont Stine-Haskell Research Center Senior Research Scientist 1996 1994-2001 Participated in the work of several research groups including insecticide discovery, natural products discovery and lead generation groups. Multistep synthesis of biologically active molecules for crop protection such as heterocycles, natural products, carbohydrates, glycosides, nucleosides, monofluoro sugars Extensive experience in heterocyclic chemistry, asymmetric synthesis, optical resolution, catalytic reactions, photochemistry Follow up work on active compounds from High Throughput Screening. Good knowledge of Structure Activity Relationships Collected relevant scientific information using STN Express, SciFinder and Beilstein Crossfire Evaluated combinatorial libraries using Spotfire Prepared technical reports, manuscripts and presentations using Microsoft Office, ISIS Base, ISIS Draw, and ChemDraw Optimized synthetic targets by utilizing molecular modeling programs such as Cerius2 Trained and supervised research associates Managed multiple research projects with external academic and industrial research groups. Created a network of international scientific research groups willing to carry out contract synthesis projects to promote business objectives Participated in the work of interdisciplinary groups with biologists and computational chemist to optimize synthetic targets Selected Research Projects   Brown University, Department of Chemistry Postdoctoral Fellowship 1992-1994 Synthesis of highly functionalized C-aryl glycoside natural products Preparation of Gilvocarcin analogues via Doetz-benzannulation reaction Implemented a method for the conversion of C-aryl glycosides into transition metal pentacarbonyl carbene complexes Mentored students, was involved in teaching activities Research Overview   University of New York at Albany, Department of Chemistry Postdoctoral Fellowship 1990-1992 Synthesized highly reactive transition metal fluorocarbene carbonyl complexes and investigated their synthetic potential in the formation of complex monofluoro ring systems, fluorinated beta lactams Established the proper structure of an unusually stable monofluoro amino carbene complex by X-ray analysis Safe handling of aggressive and air sensitive materials on a daily basis Participated in interdepartmental research projects. Synthesized a series of photochemical dies for an ongoing research project Research Overview   Richter Gedeon Pharmaceutical Works Research Scientist Senior Research Scientist 1988 1985-1990 Lead development and optimization. Multistep syntheses for pharmacologically active molecules such as antidepressants, sedatives and antihistamine compounds Process development. Alternative synthesis for existing active molecules, kilo lab preparation of advanced intermediates Supervised the work of assistant chemists Participated in the work of interdisciplinary groups with pharmacologists to optimize synthetic targets   EDUCATION   Ph.D. Medicinal Chemistry Technical University of Budapest 1990 Research Overview        M.Sc. Organic Chemistry Technical University of Budapest 1985       B.Sc. Organic Chemistry Technical University of Budapest 1983